Authors
Jintanaporn Wattanathorn, Wipawee Thukham-mee, Supaporn Muchimapura, Panakaporn Wannanon, Terdthai Tong-un, and Somsak Tiamkao
Journal
BioMed Research International
Abstract
This study aimed to determine the protective effect of cashew nut-derived protein hydrolysate with high dietary fiber (AO) in cerebral ischemic rats induced by the occlusion of right middle cerebral artery (Rt.MCAO). Acute toxicity was determined and data showed that LD50 of AO > 5000 mg/kg BW. To determine the cerebroprotective effect of AO, male Wistar rats were orally given AO at doses of 2, 10, and 50 mg/kg for 14 days and subjected to Rt.MCAO. Brain infarction volume, neurological score, spatial memory, serum lipid profiles, and C-reactive protein together with the brain oxidative stress status were assessed. All doses of AO significantly decreased brain infarction in cortex, hippocampus, and striatum together with the decreased oxidative stress status. The improvement of spatial memory and serum C-reactive protein were also observed in MCAO rats which received AO at all doses. In addition, the decreased serum cholesterol, TG, and LDL but increased HDL were observed in MCAO rats which received high dose of AO. Taken all together, AO is the potential protectant against cerebral ischemia. The improvement of oxidative stress, inflammation, and dyslipidemia might play roles in the actions. However, further researches are required to understand the precise underlying mechanism.
This study has clearly demonstrated that cashew nut-derived protein hydrolysate with high fiber (AO) is the potential cerebroprotectant against focal cerebral ischemia. The consumption safety is up to 5000 mg/kg BW. Therefore, it is practically safe. Since it can exert the effect on multitargets simultaneously, it may provide high benefit for the complex disorders such as stroke. However, further researches concerning subchronic toxicity and precise underlying mechanisms are required before moving forward to clinical study.
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